Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
Columbia University
James Swann, VetMB, DPhil
"Emergency myelopoiesis pathways as common drivers of clonal dominance and disease progression in acute myeloid leukemia"
with Emmanuelle Passegué, PhD
Aaron D. Viny, MD
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
with Emmanuelle Passegué, PhD, and Joseph G. Jurcic, MD
Icahn School of Medicine at Mount Sinai
Andrew L. Ji, MD
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
with Miriam Merad, MD, PhD
Memorial Sloan Kettering Cancer Center
Antonio Cuevas-Navarro, PhD
"Elucidating mechanisms that reverse the detrimental effect of RAS mutations in cancer"
with Piro Lito, MD, PhD
Michael V. Gormally, MD, PhD
"Immunologic targeting of 'undruggable' TP53 hotspot mutations through T cell receptor gene therapy"
with Christopher A. Klebanoff, MD, and Michael F. Berger, PhD
Tamar Kavlashvili, PhD
"Developing Tools to Mechanistically Investigate the mtDNA 'Common Deletion'"
with Agnel Sfeir, PhD
Xiaoli Mi, MD
"Origin and evolution of long-lived CAR T cells in patients with hematologic malignancies"
with Omar Abdel-Wahab, MD, and Dan A. Landau, MD, PhD
Nalin Ratnayeke, PhD
"Dissecting heterogeneous cellular responses to oncogenic KRAS inhibition in pancreatic adenocarcinoma"
with Scott W. Lowe, PhD
Santosha A. Vardhana, MD, PhD
"Overcoming metabolic suppression of anti-tumor immunity in gastric cancer"
with Charles L. Sawyers, MD
Memorial Sloan Kettering Institute for Cancer Research
Rico C. Ardy, PhD
"An atlas of fibroblast cell states in health and disease through functional genomics"
with Thomas Norman, PhD
The Rockefeller University
Nicole M. Cruz, MD
"Understanding the role of KMT2D in MLL-AF9 acute myeloid leukemia"
with Robert G. Roeder, PhD
Catherine A. Freije, PhD
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
with Charles M. Rice, PhD
California Institute of Technology
Bo Gu, PhD
"Understanding and engineering combinatorial gene regulation in mammalian cells"
with Michael B. Elowitz, PhD
Stanford University
Mohammad Balood, PhD
"Development and evaluation of T cell receptor (TCR)-based immunotherapy to target pediatric Acute Megakaryoblastic Leukemia"
with Tanja A. Gruber, MD, PhD
Debadrita Bhattacharya, PhD
"Investigating molecular and cellular mechanisms of intra-tumoral heterogeneity in small-cell lung cancer"
with Julien Sage, PhD
Felix C. Boos, PhD
"Inter-organ communication of protein homeostasis stress responses in vertebrate aging"
with Anne Brunet, PhD
Lauren E. Cote, PhD
"Constructing one continuous digestive tract, cell by cell"
with Jessica L. Feldman, PhD
Laura Crowley, PhD
"Identifying fibroblast stem cells in organ maintenance, repair, and cancer"
with Mark A. Krasnow, MD, PhD
Daniel J. Delitto, MD, PhD
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
with Michael T. Longaker, MD, DSc
Brendan Floyd, PhD
"Systematic characterization of lysosomal-targeting protein degradation"
with Carolyn R. Bertozzi, PhD
Seungsoo Kim, PhD
"Transcription factor cooperation shaping TWIST1 multifunctionality across craniofacial development and cancer metastasis"
with Joanna K. Wysocka, PhD
David S. Roberts, PhD
"Defining the molecular landscape and native interactome of the Siglec-sialoglycan axis in disease"
with Carolyn R. Bertozzi, PhD
Kavita Y. Sarin, MD, PhD
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
with Jean Y. Tang, MD, PhD, and Anthony E. Oro, MD, PhD
Melody Smith, MD
"Regulatory mechanisms of the intestinal microbiome on chimeric antigen receptor T cells"
with Robert S. Negrin, MD
Stanford University School of Medicine
Layla J. Barkal, MD, PhD
"Using commensal skin bacteria for potent, antigen-specific T cell therapy"
with Michael A. Fischbach, PhD
Steven M. Corsello, MD
"Targeting intrinsic immune signaling in pancreatic cancer with small molecule therapeutics"
with Nathanael S. Gray, PhD, and Ronald Levy, MD
Lucia Ichino, PhD
"Mechanisms underlying cis-regulatory rewiring and chromatin reorganization during epithelial to mesenchymal transition"
with Joanna K. Wysocka, PhD
Simon Sretenovic, PhD
"High-throughput precision genome editing for dissecting complex traits in yeast and human cell lines"
with Lars M. Steinmetz, PhD
Jakob Wirbel, PhD
"Microbial genome variation in hematopoietic stem-cell transplantation patients"
with Ami S. Bhatt, MD, PhD, and Michael C. Bassik, PhD
The Salk Institute for Biological Studies
Deepshika Ramanan, PhD
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
University of California, Berkeley
R. Camille Brewer, PhD
"Defining how early-life microbial encounters sculpt the B cell repertoire and shape vaccine responses"
with Gregory M. Barton, PhD
Ben F. Brian, PhD
"Mechanisms and consequences of microbiota-directed immune responses"
with Gregory M. Barton, PhD
Gabriel Cavin-Meza, PhD
"Leveraging polyploid Xenopus to probe spindle adaptation to increases in genome size"
with Rebecca W. Heald, PhD
Timothy J. Eisen, PhD
"Mechanistic dissection of Tec kinases in immune-cell signaling"
with Jay Groves, PhD and John Kuriyan, PhD
Joshua B. Sheetz, PhD
"Mitochondrial ubiquitylation mechanisms to exploit metabolic vulnerabilities in cancer"
with Michael Rape, PhD
Akanksha Thawani, PhD
"Targeted genetic supplementation by harnessing transposable elements"
with Eva Nogales, PhD, and Kathleen Collins, PhD
University of California, San Francisco
Sagar Bhattacharya, PhD
"De novo design of protease-activated anticancer proteins"
with William F. DeGrado, PhD
Fangyu Liu, PhD
"Discovery of novel ligands that treat metabolic disorders"
with Brian K. Shoichet, PhD
Tadashi Manabe, MD, PhD
"Characterization of oncogenic kinase signaling by membraneless cytoplasmic protein granules"
with Trever G. Bivona, MD, PhD
David Y. Oh, MD, PhD
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
with Lawrence Fong, MD
Philip T. Pauerstein, MD, PhD
"Enhancing immune synapse formation with synthetic adhesion to overcome chimeric antigen receptor-T cell resistance in pediatric B cell malignancies"
with Wendell A. Lim, PhD
Fanglue Peng, PhD
"Humanize CXCL13 expression in mouse to understand lymphoid neogenesis in cancer"
with Jason G. Cyster, PhD
Erron W. Titus, MD, PhD
"Engineered cellular fusogens for novel immune effector functions"
with Matthew F. Krummel, PhD
Shaohua Zhang, PhD
"Preventing tumor evasion of CAR T killing: engineering adhesion molecules to enhance cell immunotherapy"
with Wendell A. Lim, PhD
University of Colorado Boulder
Edward M. C. Courvan, PhD
"Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
with Roy R. Parker, PhD
Yale University School of Medicine
Luisa F. Escobar-Hoyos, PhD
"Understanding RNA splicing in tumor-cell adaptation and anti-tumor immunity"
The Johns Hopkins University School of Medicine
Marco A. Catipovic, PhD
"In vitro reconstitution of ribosome collision dependent signaling”
with Rachel Green, PhD
Cayla E. Jewett, PhD
"Mechanisms of centriole number control in multiciliated cells"
with Andrew J. Holland, PhD
Boston Children's Hospital
Julia Su Zhou Li, PhD
“Uncovering the link between repetitive DNA, genomic instability, and tumor viruses”
Brigham and Women's Hospital
Jordan B. Jastrab, MD, PhD
"Molecular mechanisms of inflammasome activation by intraphagosomal bacteria"
with Jonathan C. Kagan, PhD
Vignesh Shanmugam, MD
"Uncovering microenvironmental dependencies in follicular lymphoma"
with Todd R. Golub, MD
Dana-Farber Cancer Institute
April A. Apfelbaum, PhD
"Investigation of receptor tyrosine kinase-independent mechanisms of FGFR1-mediated oncogenesis in pediatric gliomas"
with Pratiti Bandopadhayay, MBBS, PhD, and Keith L. Ligon, MD, PhD
Sylvan C. Baca, MD, PhD
"Epigenetic drivers of resistance to novel therapies for bladder and kidney cancer"
with Toni K. Choueiri, MD
Kheewoong Baek, PhD
"Expansion of the glueable and degradable targets of IMiD-CRBN"
with Eric S. Fischer, PhD
Wallace A. Bourgeois, MD
"Characterizing mechanisms of resistance to Menin inhibitors in KMT2A-rearranged and NPM1-mutant AML"
with Scott A. Armstrong, MD, PhD
Anders B. Dohlman, PhD
"Identifying the genomic basis for Fusobacterium nucleatum’s colonization of colorectal cancers"
with Matthew L. Meyerson, MD, PhD
Megan L. Insco, MD, PhD
"Targeting cancer-associated aberrant RNA to treat metastatic melanoma"
with F. Stephen Hodi, MD
(Peter) Geon Kim, MD
"Elucidating the mechanisms of inflammation in clonal hematopoiesis"
with Benjamin L. Ebert, MD, PhD
Costanza Lo Cascio, PhD
"Investigating the neuronal regulation of radioresistance in diffuse midline gliomas"
with Mariella G. Filbin, MD, PhD
James J. Morrow, MD, PhD
"Application of single-cell approaches to investigate the developmental origin and early transformation steps of osteosarcoma"
with Bradley E. Bernstein, MD, PhD
Matthew G. Oser, MD, PhD
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
with William G. Kaelin, Jr., MD
Erin M. Parry, MD, PhD
"Defining follicular lymphoma transformation: molecular basis, detection and therapeutic vulnerabilities"
with Margaret A. Shipp, MD
Ahmed Roman, PhD
"Signal bottleneck theory for dissecting gene interactions in pancreatic cancer"
with Eliezer M. Van Allen, MD, and Andrew J. Aguirre, MD, PhD
Mounica Vallurupalli, MD
"Defining the mechanistic implications of SF3B1 mutations in MDS"
with Todd R. Golub, MD
Srinivas R. Viswanathan, MD, PhD
"X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer"
David M. Walter, PhD
"Identifying the selective mechanism behind U2AF1 mutations in lung adenocarcinoma"
with Matthew L. Meyerson, MD, PhD
Lachelle D. Weeks, MD, PhD
"Predicting leukemia risk from peripheral blood smears"
with Benjamin L. Ebert, MD, PhD
Nina Weichert-Leahey, MD
"Elucidating the role of KAT6A and KAT6B in the epigenetic reprogramming of neuroblastoma to enforce neuronal differentiation"
with A. Thomas Look, MD
Harvard Medical School
Erin E. Duffy, PhD
"Activity-dependent changes in RNA stability as a mechanism for synaptic plasticity"
Lucas Farnung, PhD
"Understanding the mechanistic basis of gene expression regulation by MLL complexes in cancers"
Brooke D. Huisman, PhD
"Elucidating the lineage relationships of thymic mimetic cells"
with Diane Mathis, PhD, and Christophe Benoist, MD, PhD
Manuel Osorio Valeriano, PhD
"Molecular and structural basis of gene expression regulation by the nucleosome remodeling and deacetylase (NuRD) complex in human cancer"
with Lucas Farnung, PhD, and Danesh Moazed, PhD
Harvard T.H. Chan School of Public Health
Madi Y. Cissé, PhD
"Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
with Brendan D. Manning, PhD
Harvard University
Alon Chappleboim, PhD
"Uncovering signaling mechanisms in somitogenesis through high-throughput genetic screens in robust human organoids"
with Sharad Ramanathan, PhD
Massachusetts General Hospital
Charles H. Adelmann, PhD
"Systematic exploration of the organellar and cellular requirements of pigmentation"
with David E. Fisher, MD, PhD
Albert E. Kim, MD
"Using liquid biopsy and MRI to non-invasively identify therapeutic targets for brain metastases"
with Elizabeth R. Gerstner, MD
Massachusetts Institute of Technology
Fangtao Chi, PhD
"Understanding how ketone body metabolites influence intestinal stemness, immune responses and tumorigenesis"
with Ömer H. Yilmaz, MD, PhD
Isabella Fraschilla, PhD
"Examining bacteria as a source of tumor antigens"
with Tyler E. Jacks, PhD
J. Scott P. McCain, PhD
"Estimating growth rates and fluxes using gene expression: Theory and applications"
with Gene-Wei Li, PhD
Senén D. Mendoza, PhD
"Discovery and characterization of bacterial immunity against RNA phages"
with Michael T. Laub, PhD
Expery O. Omollo, PhD
"Elucidating what determines the strength of bacterial transcription terminators"
with Gene-Wei Li, PhD
Ian J. Roney, PhD
"Discovery and characterization of bacteriophage effectors of bacterial immune systems"
with Michael T. Laub, PhD
The Broad Institute of MIT and Harvard
Chaiheon Lee, PhD
"Development of haptenizing chimeras for neoantigen generation"
with Amit Choudhary, PhD
Whitehead Institute for Biomedical Research
Jingchuan Luo, PhD
“Decoding the role of localized translation in normal physiology and cancer metastasis”
Ryan Y. Muller, PhD
"Elucidating PABPC1 sequence preferences and determining how these preferences shape gene regulation"
with David P. Bartel, PhD
University of Minnesota
Nicholas N. Jarjour, PhD
"Antigen-independent proliferation of tissue-resident memory T cells and therapeutic applications"
with Stephen C. Jameson, PhD
Princeton University
Grace E. Johnson, PhD
"Defining quorum-sensing signaling patterns and their effects on gene expression and morphology in V. cholerae biofilms at the single-cell and community levels"
with Bonnie L. Bassler, PhD
Aaron E. Lin, PhD
"Contact tracing within an organism: developing a genome editing platform to record the history of virus-infected and transformed cells"
with Alexander Ploss, PhD, and Brittany Adamson, PhD
Jeremy A. Owen, PhD
"The biophysics of substrate recognition in chromatin remodeling"
with Tom W. Muir, PhD, and Ned S. Wingreen, PhD
Titas Sengupta, PhD
"Investigating bacterial small RNA-mediated regulation of host behavior"
with Coleen T. Murphy, PhD
Carolina Trenado-Yuste, PhD
"Screening migratory modes and drug delivery schedules in 3D spheroids of triple-negative breast cancer cells"
with Celeste M. Nelson, PhD, and Ned S. Wingreen, PhD
Cheng Yang, PhD
"Chemoproteomic platforms for deciphering and drugging redox regulation between methionine and methionine sulfoxide in pancreatic cancer"
with Christopher J. Chang, PhD
Columbia University
James Swann, VetMB, DPhil
"Emergency myelopoiesis pathways as common drivers of clonal dominance and disease progression in acute myeloid leukemia"
with Emmanuelle Passegué, PhD
Aaron D. Viny, MD
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
with Emmanuelle Passegué, PhD, and Joseph G. Jurcic, MD
Icahn School of Medicine at Mount Sinai
Andrew L. Ji, MD
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
with Miriam Merad, MD, PhD
Memorial Sloan Kettering Cancer Center
Antonio Cuevas-Navarro, PhD
"Elucidating mechanisms that reverse the detrimental effect of RAS mutations in cancer"
with Piro Lito, MD, PhD
Michael V. Gormally, MD, PhD
"Immunologic targeting of 'undruggable' TP53 hotspot mutations through T cell receptor gene therapy"
with Christopher A. Klebanoff, MD, and Michael F. Berger, PhD
Tamar Kavlashvili, PhD
"Developing Tools to Mechanistically Investigate the mtDNA 'Common Deletion'"
with Agnel Sfeir, PhD
Xiaoli Mi, MD
"Origin and evolution of long-lived CAR T cells in patients with hematologic malignancies"
with Omar Abdel-Wahab, MD, and Dan A. Landau, MD, PhD
Nalin Ratnayeke, PhD
"Dissecting heterogeneous cellular responses to oncogenic KRAS inhibition in pancreatic adenocarcinoma"
with Scott W. Lowe, PhD
Santosha A. Vardhana, MD, PhD
"Overcoming metabolic suppression of anti-tumor immunity in gastric cancer"
with Charles L. Sawyers, MD
Memorial Sloan Kettering Institute for Cancer Research
Rico C. Ardy, PhD
"An atlas of fibroblast cell states in health and disease through functional genomics"
with Thomas Norman, PhD
The Rockefeller University
Nicole M. Cruz, MD
"Understanding the role of KMT2D in MLL-AF9 acute myeloid leukemia"
with Robert G. Roeder, PhD
Catherine A. Freije, PhD
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
with Charles M. Rice, PhD
University of Pennsylvania
Rahul S. Bhansali, MD
"Investigating chromatin architectural dynamics mediated by LDB1 in T-cell acute lymphoblastic leukemia"
with Gerd A. Blobel, MD, PhD
Alexander C. Huang, MD
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
with Gerald P. Linette, MD, PhD
Nicholas P. Lesner, PhD
"Hepatic urea cycle function in NASH-induced HCC progression"
with M. Celeste Simon, PhD
Rebecca S. Moore, PhD
"Investigation of the role of peripheral secreted molecules on sleep and circadian rhythms"
with Amita Sehgal, PhD
Christopher Noetzel, PhD
"How do eukaryotic cells count cell cycles? Intrinsic regulation of quantized asexual replication cycles and commitment to sexual differentiation in the protozoan parasite Cryptosporidium parvum"
with Boris Striepen, PhD
University of Pittsburgh
Yvonne M. Mowery, MD, PhD
"Evaluating and targeting pathways of treatment resistance in head and neck squamous cell carcinoma"
with Heath D. Skinner, MD, PhD, and Robert L. Ferris, MD, PhD
The University of Texas MD Anderson Cancer Center
Pavan Bachireddy, MD
"Immune evasive circuits that define MRD progression in myelodysplastic syndrome"
with Jeffrey J. Molldrem, MD
Fred Hutchinson Cancer Research Center
Edie I. Crosse, PhD
"Precision therapeutics for hematologic malignancies with splicing factor mutations"
with Robert Bradley, PhD
Christopher P. Lapointe, PhD
“Fundamental mechanisms that underlie human translation initiation and its dysregulation in cancer”
Siqi Li, PhD
"Deciphering clonal competition between oncogenic mutant and normal cells and its effect on cancer initiation"
with Slobodan Beronja, PhD
University of Washington
Wei (Will) Chen, PhD
"Decoding the transcription code: de novo protein design for precise gene regulation"
with David Baker, PhD
Nicholas C. Lammers, PhD
"A computational platform for predicting whole-embryo morphologies from single-cell transcriptomes"
with Cole Trapnell, PhD, and David Kimelman, PhD
