Dr. Molaro studies how an ancient "evolutionary arms race" between Krab-Zinc-Finger genes (KZNFs) and DNA sequence elements called retrotransposons has shaped transcriptional networks of stem cells and pluripotency. Because many cancers dedifferentiate to a stem cell-like state, refined knowledge about how KZNFs act to finely modulate transcriptional control may prove essential for the development of new cancer drugs.
Damon Runyon Researchers
Meet Our Scientists
Antoine Molaro, PhD
Project title: "Evolutionary and functional consequences of genetic conflicts between KRAB-Zinc-Fingers and endogenous retroviruses in primate genomes"
Institution: Fred Hutchinson Cancer Research Center
Award Program: Fellow
Sponsor(s) / Mentor(s): Harmit S. Malik, PhD
Cancer Type: All Cancers
Research Area: Evolution
