Damon Runyon Researchers

Dr. LaFave is studying how mutations in the SWI/SNF chromatin remodeling complex affect the initiation and progression of non-small cell lung cancer (NSCLC). Mutations in several SWI/SNF components have been identified in a variety of solid tumors; however, it remains unclear how their disruption contributes to tumor progression. She aims to develop novel NSCLC cell line and murine models to study the impact of SWI/SNF alterations. She will map the chromatin landscape in these models in order to characterize epigenetic changes that contribute to altered gene expression. These studies will lead to a greater understanding of SWI/SNF biology, potentially identifying novel therapeutic approaches for NSCLC patients.