Current and Former Awardees
Clinical Investigators2024 Recipients
Steven M. Corsello, MD
"Targeting intrinsic immune signaling in pancreatic cancer with small molecule therapeutics"
at Stanford University School of Medicine Megan L. Insco, MD, PhD
"Targeting cancer-associated aberrant RNA to treat metastatic melanoma"
at Dana-Farber Cancer Institute Mary M. Mullen, MD
"COPS5 as a novel therapeutic target in platinum-resistant ovarian cancer"
at Washington University in St. Louis Erin M. Parry, MD, PhD
"Defining follicular lymphoma transformation: molecular basis, detection and therapeutic vulnerabilities"
at Dana-Farber Cancer Institute John R. Prensner, MD, PhD
"Therapeutic opportunities and biological mechanisms for protein-RNA dyssynchrony in medulloblastoma"
at University of Michigan, Ann Arbor Lachelle D. Weeks, MD, PhD
"Predicting leukemia risk from peripheral blood smears"
at Dana-Farber Cancer Institute 2023 Recipients
Sylvan C. Baca, MD, PhD
"Epigenetic drivers of resistance to novel therapies for bladder and kidney cancer"
at Dana-Farber Cancer Institute Pavan Bachireddy, MD
"Immune evasive circuits that define MRD progression in myelodysplastic syndrome"
at The University of Texas MD Anderson Cancer Center Andrew L. Ji, MD
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
at Icahn School of Medicine at Mount Sinai Benjamin A. Nacev, MD, PhD
"Understanding and targeting chromatin reorganization in ATRX deficient sarcomas"
at University of Pittsburgh Fyza Y. Shaikh, MD, PhD
"Defining microbiome stability and longitudinal shifts as biomarkers of tumor response to immune checkpoint inhibitors across multiple malignancies"
at The Johns Hopkins University School of Medicine Santosha A. Vardhana, MD, PhD
"Overcoming metabolic suppression of anti-tumor immunity in gastric cancer"
at Memorial Sloan Kettering Cancer Center 2022 Recipients
Daniel J. Delitto, MD, PhD
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
at Stanford University Xiuning Le, MD, PhD
"Structure- and lineage-based classification and targeting of resistance in EGFR-mutant NSCLC"
at The University of Texas MD Anderson Cancer Center Nathan Singh, MD
"Tailored cellular engineering to overcome costimulation-driven CAR T cell dysfunction"
at Washington University Melody Smith, MD
"Regulatory mechanisms of the intestinal microbiome on chimeric antigen receptor T cells"
at Stanford University Aaron D. Viny, MD
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
at Columbia University 2021 Recipients
Kelly L. Bolton, MD, PhD
"The use of ivosidenib in IDH1-mutated clonal cytopenia of undetermined significance"
at Washington University School of Medicine Alexander C. Huang, MD
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
at University of Pennsylvania David Y. Oh, MD, PhD
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
at University of California, San Francisco Phillip L. Palmbos, MD, PhD
"Targeting TRIM29 to reverse immune checkpoint inhibitor resistance in bladder cancer"
at University of Michigan Sangeetha M. Reddy, MD
"Multi-modality approach to enhancing antigen presentation in breast cancers"
at University of Texas Southwestern Medical Center Daniel R. Wahl, MD, PhD
"Targeting metabolic interactions in the glioblastoma microenvironment to overcome therapy resistance"
at University of Michigan 2020 Recipients
Todd A. Aguilera, MD, PhD
"Immunologic responses to short course radiotherapy in rectal adenocarcinoma and the impact of CD40 agonist immunotherapy"
at University of Texas Southwestern Medical Center Anusha Kalbasi, MD
"IL13Ra2 Chimeric Antigen Receptor (CAR) T cells for metastatic melanoma"
at Stanford University School of Medicine Birgit Knoechel, MD, PhD
"Mechanisms of CD8+ T-cell dysfunction and its therapeutic targeting in T-ALL"
at Dana-Farber Cancer Institute Yvonne M. Mowery, MD, PhD
"Evaluating and targeting pathways of treatment resistance in head and neck squamous cell carcinoma"
at University of Pittsburgh 2019 Recipients
Karuna Ganesh, MD, PhD
"Leveraging patient-derived organoid models to define the molecular determinants of metastatic regeneration"
at Memorial Sloan Kettering Cancer Center Jennifer M. Kalish, MD, PhD
"Epigenetic and genetic mechanisms of cancer in Beckwith-Wiedemann Syndrome"
at Children's Hospital of Philadelphia David G. McFadden, MD, PhD
"Identifying metabolic vulnerabilities in Hürthle cell carcinoma"
at University of Texas Southwestern Medical Center Matthew G. Oser, MD, PhD
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
at Dana-Farber Cancer Institute Kavita Y. Sarin, MD, PhD
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
at Stanford University 2018 Recipients
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to the 3rd generation EGFR inhibitor osimertinib in lung cancer"
at University of California, San Francisco Brian C. Capell, MD, PhD
"Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis"
at University of Pennsylvania, Philadelphia Matthew D. Hellmann, MD
"Refining disease states in response to PD-1 blockade to inform rational immunotherapeutics in NSCLC"
at Memorial Sloan Kettering Cancer Center Andrew M. Intlekofer, MD, PhD
"Metabolic coupling of the hypoxic niche to stemness"
at Memorial Sloan Kettering Cancer Center Christopher A. Klebanoff, MD
"Clinical development of next-generation T cell receptor (TCR)-based adoptive immunotherapies for the treatment of patients with common epithelial malignancies"
at Memorial Sloan Kettering Cancer Center Catherine C. Smith, MD
"RNA Polymerase II as therapeutic target in AML with RAS activation"
at University of California, San Francisco 2017 Recipients
Vinod P. Balachandran, MD
"Recombinant interleukin-33 immunotherapy for pancreatic cancer"
at Memorial Sloan Kettering Cancer Center Adrienne A. Boire, MD, PhD
"Molecular determinants of leptomeningeal metastasis: a translational approach"
at Memorial Sloan Kettering Cancer Center Gavin P. Dunn, MD, PhD
"Characterizing the immunogenic landscapes of malignant brain tumors"
at Washington University Piro Lito, MD, PhD
"Modeling responses to targeted ERK signaling inhibition at the single-cell level"
at Memorial Sloan Kettering Cancer Center Mark G. Shrime, MD, MPH, PhD
"Cash transfers for cancer surgery in West Africa: their health and economic consequences"
at Massachusetts Eye and Ear Infirmary 2016 Recipients
Vivek K. Arora, MD, PhD
"Defining a targetable oncogenic dyad in bladder cancer"
at Washington University Christopher E. Barbieri, MD, PhD
"Subtype-specific modes of clinical and molecular progression in prostate cancer"
at Weill Cornell Medicine Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients"
at Stanford University Jaehyuk Choi, MD, PhD
"Development of novel therapeutic strategies for aggressive CTCL subtypes"
at Northwestern University Alex Kentsis, MD, PhD
"Mechanism and function of regulatory signaling in acute myeloid leukemia"
at Memorial Sloan Kettering Cancer Center Geoffrey R. Oxnard, MD
"Clinical translation of plasma cell-free DNA (cfDNA) genotyping technologies for NSCLC care"
at Dana-Farber Cancer Institute Heather L. Yeo, MD
"Use of mobile applications to evaluate post surgical recovery in aging patients with GI cancer"
at Weill Cornell Medicine 2015 Recipients
Priscilla K. Brastianos, MD
"Investigation of novel targeted therapeutic approaches for brain metastases"
at Massachusetts General Hospital Aude G. Chapuis, MD
"Multifaceted transgenic TCR approach to high-risk AML"
at Fred Hutchinson Cancer Research Center Marco L. Davila, MD, PhD
"The development and clinical translation of an armored CAR T cell therapy for immune-resistant B cell malignancies"
at H. Lee Moffitt Cancer Center Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies"
at Dana-Farber Cancer Institute 2014 Recipients
Arash Ash Alizadeh, MD, PhD
"Targeting the malignant reprograming of early hematopoietic progenitors to mature aggressive human B-cell lymphomas"
at Stanford University School of Medicine Joshua Brody, MD
"Flt3L-primed 'in situ' vaccination for low-grade lymphoma - Phase I/II study of intratumoral injection of rhuFlt3L and poly-ICLC with low-dose radiotherapy [NCT01976585]"
at Icahn School of Medicine at Mount Sinai L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia"
at City of Hope Alejandro Gutierrez, MD
"Mechanisms and therapeutic targeting of EZH2-dependent chemoresistance in T-ALL"
at Boston Children's Hospital Peter S. Hammerman, MD, PhD
"Development of personalized cancer immunotherapy"
at Dana-Farber Cancer Institute Luc G. Morris, MD
"Functionalizing tumor suppressor gene mutations and deletions in head and neck cancer"
at Memorial Sloan Kettering Cancer Center Stephen T. Oh, MD, PhD
"Leveraging NFkB pathway dysregulation for therapeutic benefit in myeloproliferative neoplasms"
at Washington University 2013 Recipients
Omar Abdel-Wahab, MD
"Understanding and targeting altered histone modifiers in the myeloid malignancies"
at Memorial Sloan Kettering Cancer Center Himisha Beltran, MD
"Utilizing genome sequencing to elucidate mechanisms of resistance in advanced prostate cancer"
at Weill Medical College of Cornell University Christine M. Lovly, MD, PhD
"Developing novel therapeutic strategies for ALK-fusion positive lung cancer"
at Vanderbilt University Ann Mullally, MD
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms"
at Brigham and Women's Hospital Deepak Nijhawan, MD, PhD
"Using chemistry to identify new targets in lung cancer"
at University of Texas Southwestern Medical Center Cameron J. Turtle, MD, PhD
"The impact of the colonic microbiota on reconstitution of CD161hi cells and clinical outcomes after allogeneic hematopoietic stem cell transplantation"
at Fred Hutchinson Cancer Research Center 2012 Recipients
Carey K. Anders, MD
"mTOR inhibition in the treatment of HER2-positive breast cancer brain metastases"
at University of North Carolina, Chapel Hill Oren J. Becher, MD
"Regional differences in central nervous system gliomagenesis"
at Northwestern University Sarat Chandarlapaty, MD, PhD
"Therapeutic approaches to PI3K-AKT-mTOR feedback pathways in breast cancer"
at Memorial Sloan Kettering Cancer Center Ryan B. Corcoran, MD, PhD
"Defining novel targeted therapy combination strategies for BRAF V600 mutant colorectal cancer"
at Massachusetts General Hospital Kevin B. Jones, MD
"The mitochondrial apoptosis pathway in synovial sarcoma"
at University of Utah, Salt Lake City Holbrook E. Kohrt, MD, PhD
"Augmenting anticancer antibody therapies through selective activation of NK cells"
at Stanford University 2011 Recipients
Marie Bleakley, MD, PhD
"Segregating the GVL effect from GVHD in humans"
at Fred Hutchinson Cancer Research Center Ralph J. DeBerardinis, MD, PhD
"Translational studies in cancer metabolism"
at University of Texas Southwestern Medical Center Joshua D. Schiffman, MD
"Microsatellite length and integrin signaling as risk factors for Ewing's Sarcoma"
at University of Utah, Salt Lake City Zsofia K. Stadler, MD
"Genomic assessment of de novo germline cancer susceptibility in pediatric malignancies"
at Memorial Sloan Kettering Cancer Center Jean Y. Tang, MD, PhD
"Mechanisms of acquired resistance to Hedgehog pathway inhibitors in basal cell carcinomas"
at Stanford University 2010 Recipients
Tobias J.E. Carling, MD, PhD
"Molecular genetics of endocrine tumor disease"
at Yale University School of Medicine N. Lynn Henry, MD, PhD
"Pain processing pathway analysis in aromatase inhibitor-associated musculoskeletal syndrome"
at University of Michigan, Ann Arbor Kevin R. Kozak, MD, PhD
"Radiosensitization with antiangiogenic therapy"
at University of Wisconsin, Madison Igor Matushansky, MD, PhD
"Implementing and imaging epigenetic based differentiation therapy for solid tumors"
at Columbia University Brian G. Till, MD
"Optimization of adoptive immunotherapy for lymphoma using genetically modified CD20-specific T cells"
at Fred Hutchinson Cancer Research Center 2009 Recipients
Andrew L. Feldman, MD
"Role of novel TP63 fusion genes in IRF4-positive peripheral T-cell lymphoma"
at Mayo Clinic William Y. Kim, MD
"Defining synthetic lethal targets of mTOR inhibition in renal cell carcinoma"
at University of North Carolina, Chapel Hill C. Ryan Miller, MD, PhD
"Genomics-driven drug development for glioblastoma"
at University of North Carolina, Chapel Hill Vu H. Nguyen, MD
"Organ-specific regulatory T cells as a targeted therapy for graft-versus-host disease"
at The University of Chicago 2008 Recipients
Ronald J. Buckanovich, MD, PhD
"Tumor endothelial cells as a therapeutic and diagnostic target in ovarian cancer"
at University of Michigan, Ann Arbor Andrew T. Chan, MD, MPH
"Molecular imaging of colorectal neoplasia"
at Massachusetts General Hospital Rachael A. Clark, MD, PhD
"Reversing immune evasion in human squamous cell carcinomas of the skin"
at Brigham and Women's Hospital Vassiliki Karantza, MD, PhD
"Autophagy as a therapeutic target in breast cancer treatment"
at UMDNJ/Robert Wood Johnson Medical School Elahe A. Mostaghel, MD, PhD
"Defining and exploiting molecular mechanisms of androgen-metabolism for prostate cancer therapy"
at Fred Hutchinson Cancer Research Center 2007 Recipients
Colleen Delaney, MD, MSc
“Notch-mediated ex vivo expansion of cord blood progenitors for hematopoietic cell transplantation”
at Fred Hutchinson Cancer Research Center Douglas K. Graham, MD, PhD
“Novel biologically targeted therapy against the Mer receptor tyrosine kinase in the treatment of pediatric ALL”
at University of Colorado Denver Juan Carlos Ramos, MD
“Resistance to interferon-based therapy in adult T-cell leukemia”
at University of Miami School of Medicine Joel H. Rubenstein, MD
"The epidemiology of adipokines in Barrett's esophagus”
at University of Michigan Medical School Catherine J. Wu, MD
“Immune-targeted leukemia antigens for eradication of CML stem cells”
at Dana-Farber Cancer Institute 2006 Recipients
Renier J. Brentjens, MD, PhD
“Adoptive therapy of B cell leukemias with genetically modified autologous T cells”
at Memorial Sloan Kettering Cancer Center Patrick A. Brown, MD
“Translating FLT3 inhibition into improved outcome for high risk childhood leukemia”
at Johns Hopkins University Delphine L. Chen, MD
“Apoptosis imaging”
at Washington University School of Medicine Andrea L. Cox, MD, PhD
“Analysis and manipulation of cross reactive immune responses to partial escape mutations in chronic Hepatitis C virus infection”
at Johns Hopkins University Loren S. Michel, MD
“Characterization of the Trop-2 receptor in breast cancer progression”
at Washington University School of Medicine 2005 Recipients
Marcia S. Brose, MD, PhD
"The emerging clinical role of genetics in the treatment and diagnosis of thyroid cancer"
at University of Pennsylvania, Philadelphia Christine H. Chung, MD
"Gene expression-based outcome prediction in head and neck cancer"
at Vanderbilt University Medical Center Phillip G. Febbo, MD
"Mechanisms of docetaxel resistance in metastatic prostate cancer"
at Duke University Medical Center John M. Pagel, MD, PhD
"Radioimmunotherapy of CD45+ leukemias"
at Fred Hutchinson Cancer Research Center John M. Timmerman, MD
"Dendritic cell-based outcome prediction in head and neck cancer"
at University of California, Los Angeles 2004 Recipients
Charles G. Drake, MD, PhD
"Integrating clinical and laboratory studies to develop immunotherapy for prostate cancer"
at Johns Hopkins University Jakob Dupont, MD
"Development and analysis of tumor-specific T cells for adoptive immunotherapy of epithelial ovarian cancer"
at Memorial Sloan Kettering Cancer Center John V. Heymach, MD, PhD
"VEGF receptor inhibitors for non-small cell lung cancer: clinical studies and novel surrogate markers of activity"
at M.D. Anderson Cancer Center Jeremy N. Rich, MD
"Maximizing clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma therapy"
at Cleveland Clinic Foundation 2003 Recipients
Scott A. Armstrong, MD, PhD
“Genomic identification of new therapeutic targets in leukemia”
at Boston Children's Hospital Peter D. Cole, MD
“Improving the therapeutic index for children with acute lymphoblastic leukemia through studies of folate physiology and antifolate pharmacodynamics”
at Albert Einstein College of Medicine Dean W. Felsher, MD, PhD
“Targeting MYC for the treatment of lymphoma”
at Stanford University School of Medicine Jedd D. Wolchok, MD, PhD
“Clinical development of DNA vaccines for melanoma”
at Memorial Sloan Kettering Cancer Center 2002 Recipients
Madhav V. Dhodapkar, MD
“Anti-tumor immunity in myeloma”
at The Rockefeller University William M. Grady, MD
“Novel molecular screening and surveillance methods for colorectal cancer”
at Fred Hutchinson Cancer Research Center Albert C. Koong, MD, PhD
“Modulation of protein kinase C as a novel hypoxia-specific therapeutic strategy”
at Stanford University School of Medicine Sridhar Mani, MD
“Molecular and phenotypic dose adaptation models in the clinical development of novel microtubule binding agents”
at Albert Einstein College of Medicine James M. Olson, MD, PhD
“Predicting retinoid-responsive medulloblastoma patients”
at Fred Hutchinson Cancer Research Center 2001 Recipients
Joseph A. Califano, III, MD
“Molecular screening in a population at risk for head and neck cancer”
at The Johns Hopkins University School of Medicine Li Li, MD, PhD
“Diet, methylenetetrahydrofolate reductase, genomic DNA methylation, and five most promising novel candidate genes in the carcinogenesis of colon neoplasia”
at Case Western Reserve University Jennifer L. Malin, MD
“Quality of chemotherapy care for cancer: evaluating underuse, overuse and misuse”
at University of California, Los Angeles William R. Sellers, MD
“The molecular classification of prostate cancer”
at Dana-Farber Cancer Institute Cassian Yee, MD
“Adoptive T-cell therapy of melanoma”
at Fred Hutchinson Cancer Research Center 2000 Recipients
Rafael Fonseca, MD
“Genomic instability in plasma cell dyscrasias”
at Mayo Clinic, Scottsdale Maura L. Gillison, MD, PhD
“Establishing a casual association between HPV and HNSCC”
at The Johns Hopkins University School of Medicine Vered Stearns, MD
“Surrogate markers as endpoints: novel clinical design for combining standard and novel therapies in breast cancer”
at The Johns Hopkins University School of Medicine Robert H. Vonderheide, MD, PhD
“Clinical evaluation of telomerase as a widely expressed tumor-associated antigen linked to oncogenesis”
at University of Pennsylvania, Philadelphia Edus “Hootie” Warren, MD, PhD
“Antigen-specific T-cell therapy for leukemia”
at Fred Hutchinson Cancer Research Center 
