Azad Bonni, MD, PhD (Damon Runyon Fellow ’96-’97) of Washington University School of Medicine, St. Louis, and colleagues, were the first to show that a protein called OSMR (Oncostatin M Receptor) is required for glioblastoma tumors to form. They found that blocking OSMR activity in brain tumor stem cells prevented them from forming tumors in mouse brains. In addition, an analysis of 339 tumor samples from human glioblastoma patients showed that higher OSMR expression corresponded with worse patient survival outcome. They plan to next develop small molecules or antibodies that can shut down the OSMR protein as a novel therapeutic strategy for treatment of glioblastoma. The study was published in Nature Neuroscience.
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